An in vitro study finds that nitric oxide may suppress SARS-CoV-2, the virus that causes COVID-19. The researchers suggest that inhaled nitric oxide may be an effective treatment for the disease and can be even a good prevention method but still we are waiting for some studies to been done but still these are good news for the millions of people like me, Elon Musk and Jair Bolsonaro, the president of Brasil that will not take any type of vaccine.
The next article is a summary of investigations that I gathered online from recognized media that share medical news so you can rest assured about the credibility of the information. At the end of this article there are tips to increase your Nitric Oxide production but before delve deep into the topic. It is very important that you know that Nitric Oxide is essential for having a healthy cardiovascular system and with aging the production is reduced increasing the probabilities of a heart stroke.
Mouth breathing does not let our bodies take advantage of the sinuses production of Nitric Oxide. Our bodies increase the production of Nitric Oxide by breathing with the nose.
Also, oral bacteria play an essential role in the conversion process from nitrate (NO3-) and nitrite (NO2-) to nitric oxide (NO). Unfortunately, mouthwash kills all types of bacteria, including the beneficial ones that help produce nitric oxide. Research has shown that mouthwash kills the oral bacteria needed to produce nitric oxide for up to 12 hours. This leads to a decrease in nitric oxide production and, in some instances, an increase in blood pressure. Which can lead to serious heart problems. So I advise you not to use them, it is a serious issue.
1 - COVID-19: Nitric oxide shows promise as antiviral treatment
Researchers at Uppsala University have found that an effective way of treating the coronavirus COVID-19. The substance concerned is nitric oxide (NO), a compound with antiviral properties that is produced by the body itself. The study is published in the journal Redox Biology.
Both antibacterial and antiviral
Nitric oxide (NO) is a compound produced naturally in the body. Its functions include acting like a hormone in controlling various organs. It regulates, for example, tension in the blood vessels and blood flow between and within organs. In acute lung failure, NO can be administered as inhaled gas, in low concentrations, to boost the blood-oxygen saturation level. During the SARS (severe acute respiratory syndrome) coronavirus epidemic of 2003, this therapy was tried out with success. One key reason for the successful results was that inflammation in the patients’ lungs decreased. This property of nitric oxide – the protection it affords against infections, by being both antibacterial and antiviral – is the very one that now interests the researchers.
2 - Can Nitric Oxide Prevent COVID-19 Infection or Progression ?
Nitric oxide is FDA-approved for use in premature and term neonates with persistent pulmonary hypertension, but it has also been used off-label for decades in the adult ICU and operating room to treat patients with pulmonary arterial hypertension, acute respiratory distress syndrome, hypoxia, and right ventricular failure after cardiac surgery or lung transplantation.
Are you using NO for the prevention of Covid-19, What's the basis for that ?
In this disease, regardless of the oxygenation response, NO has the potential to be virucidal against the coronavirus responsible for COVID-19 disease. So we are not giving NO just for the improvement of oxygenation, which we usually observe, but also for this antiviral effect.
The most appealing potential effect of NO for COVID-19 that now needs confirmation is its antiviral action. Back in 2003–2004 during the SARS outbreak in China, a group of clinicians used NO in patients with SARS ARDS. Physicians reported that the chest X-rays of patients who had been given inhaled NO cleared much faster. Oxygenation improved, and the effect was lasting. In their report, the authors said they had never seen anything like that before with NO. Usually, there is an acute response of improved oxygenation, but not a rapid clearing of the chest x-ray. We began to question whether NO actually might have virucidal effects in COVID19.
Other groups tested the effects of NO donor drugs in patients infected with coronavirus species and found that the virus cleared faster and there was survival of eukaryotic cells. A similar effect has been shown in children with viral bronchiolitis, in whom a high dose (160 ppm) of NO gas led to clearing of the infection. A typical dose for children and adults in the ICU is from 5 ppm to 20 ppm. The maximum dose recommended by the FDA is 80 ppm — so we are talking about double or even higher doses of NO. In high dose Nitric Oxide is safe.
Does Nitric Oxide(NO) have any systemic effects or potential adverse effects that must be monitored?
When NO gas mixes with oxygen as it is delivered to the patient, it forms nitrogen dioxide, which is toxic to lung tissue at over 2 ppm. Thus, we are monitoring nitrogen dioxide levels in all study patients.
NO gas is quickly metabolized by hemoglobin when it comes into contact with the lungs. It's immediately converted to nitrate and nitrite, which are eventually cleared by the kidneys. Inhaled NO has no systemic hemodynamic effects about which we are aware.
This is an interview that Medscape did to the anesthesiologist Lorenzo Berra, MD, medical director of respiratory care at Massachusetts General Hospital and the Reginald Jenney Associate Professor of Anesthesia at Harvard Medical School, about his research, which aims to clarify the role of Nitric Oxide gas in the prevention and treatment of COVID-19. The complete interview is on this link.
3 - NOviricid can improve COVID-19 patient outcomes and survival in 840 recently diagnosed African American patients with comorbidities
Dr Nathan Bryan, Founder and Chief Executive Officer of NOI, stated: “Everything we have learned about COVID-19 over the past 10 months reveals that diminished nitric oxide production in patients is what is thought to be responsible for the increased risk of infection and rapid disease progression.
This applies directly to the African American population, which often suffers from diminished nitric oxide production. A lack of nitric oxide explains the multi-system disease and dysfunction that persists long after the active infection is gone, including increased risk of blood clots, endotheliitis, kidney and lung dysfunction. Restoration of nitric oxide appears to be a very safe and effective solution.”
The organisation stated that recent and ongoing studies have shown that NO administration inhibits SARS-CoV-2 replication. They added that while inhaled NO has been used successfully to treat severe COVID-19 patients on ventilators, the expense and complicated delivery technique (requiring a hospital setting) makes it an impractical strategy to treat patients recently diagnosed with COVID-19. They suggest that in contrast, their investigational oral lozenge NOviricid could be administered before patients become critically ill, ideally within 72 hours of a positive COVID-19 test.
This is a summary from an article published by the European Pharmacetical Review. Now is time to talk about some tips to increase the natural production of Nitric Oxide by our bodies.
The best foods to boost your nitric oxide levels are
Beets
Beets are rich in dietary nitrates, which your body can convert to nitric oxide. According to one study in 38 adults, consuming a beetroot juice supplement increased nitric oxide levels by 21% after just 45 minutes.
Similarly, another study showed that drinking 3.4 ounces (100 ml) of beetroot juice significantly increased nitric oxide levels in both men and women. Thanks to their rich content of dietary nitrates, beets have been linked to a number of health benefits, including improved cognitive function, enhanced athletic performance, and lower blood pressure levels.
Garlic
Garlic can boost nitric oxide levels by activating nitric oxide synthase, the enzyme that aids in the conversion of nitric oxide from the amino acid L-arginine.
One animal study showed that aged garlic extract temporarily increased blood nitric oxide levels by up to 40% within an hour of consumption.
Dark Chocolate
One 15-day study in 16 people showed that consuming 30 grams of dark chocolate daily led to significant increases in nitric oxide levels in the blood.
What’s more, participants experienced decreases in both systolic and diastolic blood pressure levels — the top and bottom number of the blood pressure reading.
Because of its rich content of nitric-oxide-boosting flavanols, dark chocolate has been associated with improved blood flow, enhanced brain function, and a lower risk of heart disease, too.
Leafy Greens
Leafy green vegetables like spinach, arugula, kale and cabbage are packed with nitrates, which are converted to nitric oxide in your body. One study even showed that eating a nitrate-rich meal containing spinach increased salivary nitrate levels eightfold and significantly decreased systolic blood pressure.
Other research has found that consuming high-nitrate leafy greens may also be associated with a reduced risk of heart disease and cognitive decline.
Citrus Fruits
Vitamin C can enhance levels of nitric oxide by increasing its bioavailability and maximizing its absorption in the body. Citrus fruits like oranges, lemons, limes and grapefruit are all excellent sources of vitamin C, an important water-soluble vitamin that plays a central role in health.
Pomegranate
One test-tube study showed that pomegranate juice was effective in protecting nitric oxide from oxidative damage while also increasing its activity.
Another animal study found that both pomegranate juice and pomegranate fruit extract were able to increase levels of nitric oxide synthase and boost the concentration of nitrates in the blood.
Watermelon
Watermelon is one of the best sources of citrulline, an amino acid that’s converted to arginine and, ultimately, nitric oxide in your body.
One small study found that citrulline supplements helped stimulate nitric oxide synthesis after just a few hours but noted that it may take longer to see positive effects on health.
Meanwhile, another study in eight men showed that drinking 10 ounces (300 ml) of watermelon juice for two weeks led to significant improvements in nitric oxide bioavailability.
Nuts and Seeds
Nuts and seeds are high in arginine, a type of amino acid that is involved in the production of nitric oxide. Some research suggests that including arginine from foods like nuts and seeds in your diet can help increase nitric oxide levels in your body.
For example, one study in 2,771 people showed that a higher intake of arginine-rich foods was associated with higher levels of nitric oxide in the blood. Another small study found that supplementing with arginine increased levels of nitric oxide after just two weeks.
L-Argenine
This amino acid is converted into Nitric Oxide inside the body. I am taking this supplement every night before sleeping to increase the production of Growth Hormone during sleep. I am a Spiritual Health coach helping people to rejuvenate their bodies so they can be healthier, younger, more beautiful, and they can live longer. Then I am experimenting with a lot of natural compounds before recommending them to my clients, L-Arginine is one of them.
But to be sincere this is one of the compounds I never recommended before to my patients because I know other compounds more powerful to rejuvenate and to activate certain hormones and proteins that help to rejuvenate, heal and produce healthy cells. If you want to rejuvenate your body and increase your life span contact to me at pranachy@protonmail.com
As you see I am having a higher perspective than mainstream medicine which is focused on curing diseases while my approach is to prevent them with natural remedies, a good example is this article I published with "10 tips to triple the resistance of the immune system in case it needs to fight the Coronavirus".
Since most of you are so busy with your lives, having a holistic health coach like myself researching life-prolonging and rejuvenating remedies every day is a huge investment of money and time. And the best method to maintain good health, look more beautiful and live longer in perfect shape "naturally".
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